Oral administration of D-alanine in monkeys robustly increases plasma and cerebrospinal fluid levels but experimental D-amino acid oxidase inhibitors had minimal effect

We report that while oral D-alanine administration to baboons (10 mg/kg) enhanced D-alanine plasma and CSF levels over 20-fold versus endogenous levels, addition of experimental DAAOi to the regimen exhibited a 2.2-fold enhancement in plasma and no measurable effect on CSF levels. The results provide caution regarding the utility of DAAO inhibition to increase D-amino acid levels as treatment for patients with schizophrenia.

Source: Journal of Psychopharmacology - August 21, 2016 Category: Psychiatry Authors: Rojas, C., Alt, J., Ator, N. A., Wilmoth, H., Rais, R., Hin, N., DeVivo, M., Popiolek, M., Tsukamoto, T., Slusher, B. S. Tags: Original Papers Source Type: research