Angiogenesis Imaging Using 68Ga-RGD PET/CT: Therapeutic Implications

Angiogenesis imaging is important for diagnostic and therapeutic treatment of various malignant and nonmalignant diseases. The Arg-Gly-Asp (RGD) sequence has been known to bind with the αvβ3 integrin that is expressed on the surface of angiogenic blood vessels or tumor cells. Thus, various radiolabeled derivatives of RGD peptides have been developed for angiogenesis imaging. Among the various radionuclides, 68Ga was the most widely studied for RGD peptide imaging because of its e xcellent nuclear physical properties, easy-to-label chemical properties, and cost-effectiveness owing to the availability of a 68Ge-68Ga generator.
Source: Seminars in Nuclear Medicine - Category: Nuclear Medicine Authors: Source Type: research