Systems proteomic analysis reveals that Clusterin and Tissue Inhibitor of Metalloproteinases 3 increase in leptomeningeal arteries affected by cerebral amyloid angiopathy

ConclusionsGlobal proteomic profiling of brain leptomeningeal arteries revealed that clusterin and TIMP3 increase in leptomeningeal arteries affected by CAA. We propose that clusterin and TIMP3 could facilitate perivascular clearance and may serve as novel candidate therapeutic targets for cerebral amyloid angiopathy.This article is protected by copyright. All rights reserved.

Source: Neuropathology and Applied Neurobiology - July 31, 2016 Category: Neurology Authors: Antigoni Manousopoulou, Maureen Gatherer, Colin Smith, James A.R. Nicoll, Christopher H. Woelk, Mary Johnson, Rajesh Kalaria, Johannes Attems, Spiros D. Garbis, Roxana O. Carare Tags: Original Article Source Type: research