General lack of use of placebo in prophylactic, randomised, controlled trials in adult migraine. A systematic review

Conclusions The majority of comparative, prophylactic migraine RCTs do not include a placebo arm. Failure to include a placebo arm may result in failure to demonstrate efficacy of potentially effective migraine-prophylactic agents. In order to benefit current and future patients, the current strong tendency to omit placebo-controls in these RCTs should be replaced by adherence to the guidelines of the IHS.
Source: Cephalalgia - Category: Neurology Authors: Tags: Review Articles Source Type: research