Responses of dural mast cells in concussive and blast models of mild traumatic brain injury in mice: Potential implications for post-traumatic headache

Conclusions
mTBI evoked by closed head injury or blast exposure is associated with persistent dural MC degranulation. Such a response in mTBI patients may contribute to PTH. Amelioration of PTH by sumatriptan may not involve inhibition of dural MC degranulation. If persistent dural MC degranulation contributes to PTH, then cromolyn treatment may not be effective.

Source: Cephalalgia - August 18, 2016 Category: Neurology Authors: Levy, D., Edut, S., Baraz-Goldstein, R., Rubovitch, V., Defrin, R., Bree, D., Gariepy, H., Zhao, J., Pick, C. G. Tags: Original Articles Source Type: research