Triglyceride Treatment in the Age of Cholesterol Reduction

Cholesterol reduction has markedly reduced major cardiovascular disease (CVD) events and shown regression of atherosclerosis in some studies. However, CVD has for decades also been associated with increased levels of circulating triglyceride (TG)-rich lipoproteins. Whether this is due to a direct toxic effect of these lipoproteins on arteries or whether this is merely an association is unresolved. More recent genetic analyses have linked genes that modulate TG metabolism with CVD. Moreover, analyses of subgroups of hypertriglyceridemic (HTG) subjects in clinical trials using fibric acid drugs have been interpreted as evidence that TG reduction reduces CVD events.

Source: Progress in Cardiovascular Diseases - August 17, 2016 Category: Cardiology Authors: Nidhi Agrawal, Patricia Freitas Corradi, Namrata Gumaste, Ira J. Goldberg Source Type: research