Conjugate addition of malononitrile on chalcone: Biocatalytic CC bond formation

Publication date: November 2016 Source:Journal of Molecular Catalysis B: Enzymatic, Volume 133 Author(s): Nitesh D. Punyapreddiwar, Sangesh P. Zodape, Atul V. W.hade, Umesh R. Pratap An efficient, cost effective and environmentally friendly protocol has been developed for the Michael addition of malononitrile on 1,3-diaryl-2-propen-1-ones (Chalcones) using very cheaper, easily available natural catalyst, baker’s yeast. The whole cells of yeast excellently worked in nonaqueous medium, ethanol without decrease in catalytic activity. Graphical abstract
Source: Journal of Molecular Catalysis B: Enzymatic - Category: Biochemistry Source Type: research