Genetic Modifiers for the Long-QT Syndrome: How Important Is the Role of Variants in the 3' Untranslated Region of KCNQ1? [Original Articles]

Conclusions— 3' Untranslated region SNPs are not acting as genetic modifiers in a large group of LQT1 patients. The confounding effect of merging a genetically and clinically heterogeneous group of patients needs to be taken into account when studying disease modifiers.

http://circgenetics.ahajournals.org/cgi/content/short/9/4/330?rss=1

Source: Circulation: Cardiovascular Genetics - August 15, 2016 Category: Cardiology Authors: Crotti, L., Lahtinen, A. M., Spazzolini, C., Mastantuono, E., Monti, M. C., Morassutto, C., Parati, G., Heradien, M., Goosen, A., Lichtner, P., Meitinger, T., Brink, P. A., Kontula, K., Swan, H., Schwartz, P. J. Tags: Arrhythmias, Ion Channels/Membrane Transport, Mechanisms, Risk Factors, Genetic, Association Studies Original Articles Source Type: research