Dietary butyrylated high-amylose starch reduces azoxymethane-induced colonic O6-methylguanine adducts in rats as measured by immunohistochemistry and high-pressure liquid chromatography

In this study, we hypothesized that a dietary intervention that specifically delivers butyrate to the large bowel (notably butyrylated high-amylose maize starch [HAMSB]) would reduce colonic levels of O6MeG in rats shortly after exposure to the deoxyribonucleic acid (DNA) alkylating agent azoxymethane (AOM) when compared with a low-amylose maize starch (LAMS).

Source: Nutrition Research - June 6, 2016 Category: Nutrition Authors: Richard K. Le Leu, Benjamin L. Scherer, Mark T. Mano, Jean M. Winter, Tamsin Lannagan, Richard J. Head, Trevor Lockett, Julie M. Clarke Tags: Original Research Source Type: research