Total synthesis, structural, and biological evaluation of stylissatin A and related analogs
We report here the solid‐phase synthesis, structural studies, and biological evaluation of cyclic peptides stylissatin A, proline rotamer of stylissatin A, (D‐allo‐Ile2)‐stylissatin A, and six analogues of stylissatin A. The position of macrocyclization was found to influence the proline rotamer population of synthetic sytlissatin A. The synthetic stylissatin A, its epimer and trans, trans rotamer potently inhibited the NO. production. Related analogues of stylissatin A were identified as more potent inhibitors of interleukin 2 release.
Source: Journal of Peptide Science - Category: Biochemistry Authors: Farzana Shaheen, Almas Jabeen, Samreen Ashraf, Muhammad Nadeem ‐ul‐Haque, Zafar Ali Shah, Muhammad Asad Ziaee, Nida Dastagir, A. Ganesan Tags: Research Article Source Type: research