Total synthesis, structural, and biological evaluation of stylissatin A and related analogs

We report here the solid‐phase synthesis, structural studies, and biological evaluation of cyclic peptides stylissatin A, proline rotamer of stylissatin A, (D‐allo‐Ile2)‐stylissatin A, and six analogues of stylissatin A. The position of macrocyclization was found to influence the proline rotamer population of synthetic sytlissatin A. The synthetic stylissatin A, its epimer and trans, trans rotamer potently inhibited the NO. production. Related analogues of stylissatin A were identified as more potent inhibitors of interleukin 2 release.
Source: Journal of Peptide Science - Category: Biochemistry Authors: Tags: Research Article Source Type: research