Cynanchum wilfordii Radix attenuates liver fat accumulation and damage by suppressing hepatic cyclooxygenase-2 and mitogen-activated protein kinase in mice fed with a high-fat and high-fructose diet

Excessive consumption of fat and fructose augments the pathological progression of nonalcoholic fatty liver disease through hepatic fibrosis, inflammation, and hepatic de novo lipogenesis. We hypothesized that supplementation with Cynanchum wilfordii extract (CWE) decreases fat accumulation in the liver by suppressing cyclooxygenase-2 (COX-2), the nuclear translocation of nuclear factor κB (NF-κB), and p38 mitogen-activated protein kinase (MAPK). The beneficial effect of CWE was evaluated in a murine model of nonalcoholic fatty liver disease.

Source: Nutrition Research - June 11, 2016 Category: Nutrition Authors: Seon-A Jang, SungRyul Lee, Eun-Hwa Sohn, Jaehyuk Yang, Dae Won Park, Yong Joon Jeong, Inhye Kim, Jung Eun Kwon, Hae Seong Song, Young Mi Cho, Xue Meng, Hyun Jung Koo, Se Chan Kang Source Type: research