A vitamin D pathway gene-gene interaction affects low-density lipoprotein cholesterol levels

Much evidence suggests an association between vitamin D deficiency and chronic diseases such as obesity and dyslipidemia. Although genetic factors play an important role in the etiology of these diseases, only a few studies have investigated the relationship between vitamin D related-genes and anthropometric and lipid profiles. The aim of this study was to investigate the association of three vitamin D-related genes with anthropometric and lipid parameters in 542 adult individuals. We analyzed the rs2228570 polymorphism in the vitamin D receptor gene (VDR), rs2134095 in the retinoid X receptor gamma gene (RXRG), and rs7041 in the vitamin D-binding protein gene (GC).
Source: The Journal of Nutritional Biochemistry - Category: Biochemistry Authors: Source Type: research