Proanthocyanidins Block Aldosterone-Dependent Upregulation of Cardiac Gamma Enac and Nedd4 –2 Inactivation Via Sgk1

Aldosterone plays a central role in the development of cardiac pathological states involving ion transport imbalances, especially sodium transport. We have previously demonstrated a cardioprotective effect of proanthocyanidins in aldosterone-treated rats. Our objective was to investigate for the first time, the effect of proanthocyanidins on serum and glucocorticoid regulated kinase type 1 (SGK1), epithelial Na+channel ( γ-ENac), neuronal precursor cells expressed developmentally down-regulated 4–2 (Nedd4–2) and phosphoNedd4–2 protein expression in the hearts of aldosterone-treated rats.

Source: The Journal of Nutritional Biochemistry - August 13, 2016 Category: Biochemistry Authors: Adri án Galiana-Simal, Elena Olivares-Álvaro, Mercedes Klett-Mingo, María Belén Ruiz-Roso, Sandra Ballesteros, Natalia de las Heras, Peter J. Fuller, Vicente Lahera, Beatriz Martín-Fernández Source Type: research