Suppression of TH17-mediated pathology through BET bromodomain inhibition

Publication date: Available online 13 August 2016 Source:Drug Discovery Today: Technologies Author(s): Srimoyee Ghosh, Jose M. Lora Epigenetic control of gene expression is enforced in part through histone modifications. Bromodomain and extra terminal domain (BET) proteins function as crucial chromatin readers, responsible for interpretation of the chromatin code in diverse cellular contexts, ultimately impacting gene transcription. BET proteins can play a major role in inflammation by profoundly affecting the biology of the Thelper 17 (TH17) lineage. We summarize recent studies focusing on BET inhibition as a viable therapeutic alternative for the control of autoimmune diseases driven by aberrant activation of TH17 cells.
Source: Drug Discovery Today: Technologies - Category: Drugs & Pharmacology Source Type: research