Clonidine and ketamine for stable hemodynamics in off-pump coronary artery bypass

Conclusions Combined low-dose clonidine and ketamine produced perioperative sedation and effective suppression of sympathetic response with stable hemodynamics. Intraoperative beta-blocker use was reduced without increasing inotrope requirement. This combination prolonged the analgesic effect of opioids, reducing postoperative pain score and analgesic requirement. Low-dose clonidine alone produced sedation but did not completely block sympathetic response. Intensive care unit stay and patient outcome were not affected by clonidine or ketamine.
Source: Asian Cardiovascular and Thoracic Annals - Category: Cardiology Authors: Tags: Cardiac Source Type: research