4‐O‐methylhonokiol Inhibits Serious Embryo Anomalies Caused by Nicotine via Modulations of Oxidative Stress, Apoptosis, and Inflammation

CONCLUSIONSThese findings indicate that 4‐O‐methylhonokiol reduces serious embryo anomalies caused by nicotine in mouse embryos via the modulations of oxidative stress, apoptosis, and inflammation, suggesting that 4‐O‐methylhonokiol may be a preventive and therapeutic agent against the dysmorphology induced by maternal smoking during pregnancy.

Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology - April 1, 2014 Category: Perinatology & Neonatology Authors: Chunmei Lin, Jung‐Min Yon, Jin Tae Hong, Jong Kwon Lee, Jayoung Jeong, In‐Jeoung Baek, Beom Jun Lee, Young Won Yun, Sang‐Yoon Nam Tags: Research Article Source Type: research