Absence of Irreversible Effects of Aliskiren in Standard Juvenile Rat Toxicity Studies

CONCLUSIONSAll effects produced by aliskiren, including kidney effects, were reversible. Increased exposure in very young animals is considered to be the result of immature drug transporter systems.

Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology - February 1, 2014 Category: Perinatology & Neonatology Authors: David Beckman, Stephanie Barbeau, Lee Anne McLean, Jing‐He Yan, Peter Hoffmann Tags: Research Article Source Type: research