Effect of fish oil on lateral mobility of prostaglandin F2 α (FP) receptors and spatial distribution of lipid microdomains in bovine luteal cell plasma membrane in vitro1

Lipid microdomains are ordered regions on the plasma membrane of cells, rich in cholesterol and sphingolipids, ranging in size from 10 to 200 nm in diameter. These lipid-ordered domains may serve as platforms to facilitate co-localization of intracellular signaling proteins during agonist-induced signal transduction. It is hypothesized that fish oil will disrupt the lipid microdomains, increasing spatial distribution of these lipid-ordered domains and lateral mobility of the prostaglandin (PG) F2 α (FP) receptors in bovine luteal cells.
Source: Domestic Animal Endocrinology - Category: Endocrinology Authors: Source Type: research