Nicotine Enhances Footshock- and Lithium Chloride-Conditioned Place Avoidance in Male Rats

Conclusions: These results demonstrate that the ability of NIC to enhance motivated behavior extends to behaviors elicited by aversive stimuli, evidence that NIC affects behavior motivated by a broader range of stimuli than previously appreciated. Implications: The current study examined whether the reinforcement enhancement properties of NIC apply to aversive stimuli by testing NIC enhancement of conditioned place avoidance in rats. The results demonstrate that NIC enhances the motivational impact of these distinct aversive stimuli, providing novel evidence that NIC affects behavior motivated by a broader range of stimuli than has previously been demonstrated.

http://ntr.oxfordjournals.org/cgi/content/short/18/9/1920?rss=1

Source: Nicotine and Tobacco Research - August 9, 2016 Category: Addiction Authors: Buffalari, D. M., Mollica, J. K., Smith, T. T., Schassburger, R. L., Rinaman, L., Thiels, E., Donny, E. C., Sved, A. F. Tags: Brief Report Source Type: research