The Effect of Different Case Definitions of Current Smoking on the Discovery of Smoking-Related Blood Gene Expression Signatures in Chronic Obstructive Pulmonary Disease

Conclusion:
A combined phenotype of eCO and self report allows for better discovery of genes and pathways related to current smoking.

Implications:
Studies relying only on self report of smoking status to assess or adjust for the impact of smoking may not fully capture its effect and will lead to residual confounding of results.

Source: Nicotine and Tobacco Research - August 9, 2016 Category: Addiction Authors: Obeidat, M., Ding, X., Fishbane, N., Hollander, Z., Ng, R. T., McManus, B., Tebbutt, S. J., Miller, B. E., Rennard, S., Pare, P. D., Sin, D. D. Tags: Original Investigation Source Type: research