Ablation of interaction between IL-33 and ST2+ regulatory T cells increases immune cell-mediated hepatitis and activated NK cell liver infiltration

In conclusion, IL-33 acts as a potent immune modulator protecting the liver through activation of ST2+ Treg cells and control of NK cells.

Source: AJP: Gastrointestinal and Liver Physiology - August 8, 2016 Category: Gastroenterology Authors: Noel, G., Arshad, M. I., Filliol, A., Genet, V., Rauch, M., Lucas-Clerc, C., Lehuen, A., Girard, J.-P., Piquet-Pellorce, C., Samson, M. Tags: INFLAMMATION, IMMUNITY, AND INFECTION Source Type: research