Comparative Evaluation of 4 and 6-Carbon Spacer Conformationally-Flexible Tetrahydroisoquinolinyl Benzamide Analogues for Imaging the Sigma-2 Receptor Status of Solid Tumors

Nine novel analogues were synthesized including a 6-carbon spacer analogue of ISO-1 (7). They have moderate binding affinity for sigma-2 ( σ2) receptors and high selectivity for σ2 receptors relative to sigma-1 (σ1) receptors.

Source: Nuclear Medicine and Biology - August 8, 2016 Category: Nuclear Medicine Authors: Iljung Lee, Brian P. Lieberman, Shihong Li, Catherine Hou, Mehran Makvandi, Robert H. Mach Source Type: research