Analysis of Gene Expression in the Endocervical Epithelium of Women With Deep Endometriosis

In this study, we analyzed gene expression in the endocervical epithelium in women with and without moderate or severe endometriosis. Using RT2 Profiler PCR Arrays, we analyzed gene expression in endocervical epithelial cells from women with deep endometriosis (n = 4) and healthy women (n =6). Nine genes were identified as being upregulated: 5 cell cycle genes (cyclin B1 [CCNB1], cyclin G1 [CCNG1], cullin 1 [CUL1], general transcription factor IIH, polypeptide 1 [GTF2H1], and proliferating cell nuclear antigen [PCNA]), 3 cytokine genes (C3, chemokine (C-C motif) ligand 21 [CCL21], and chemokine (C-X-C motif) ligand 14 [CXCL14]) and 1 gene related to dendritic cell pathways (ICAM2), showing that differential gene expression is present in the endocervical epithelium of women with deep endometriosis.

Source: Reproductive Sciences - August 8, 2016 Category: Reproduction Medicine Authors: Kopelman, A., Girao, M. J. B. C., Bonetti, T. C. S., Carvalho, C. V., da Silva, I. D. C. G., Schor, E. Tags: Original Articles Source Type: research