Preeclampsia and Inflammatory Preterm Labor Alter the Human Placental Hematopoietic Niche

Conclusion:
Placental HSPCs likely arise from hematopoietic niches comprised RUNX1+ mesenchyme and vascular endothelium. Pregnancy complications that result in preterm birth differentially affect placental HSPC localization and RUNX1 expression. Our results support previous findings that inflammation positively regulates hematopoiesis. We present new evidence that hemogenic endothelium may be active at later stages of human fetal development in the context of inflammation.

Source: Reproductive Sciences - August 8, 2016 Category: Reproduction Medicine Authors: Ponder, K. L., Barcena, A., Bos, F. L., Gormley, M., Zhou, Y., Ona, K., Kapidzic, M., Zovein, A. C., Fisher, S. J. Tags: Original Articles Source Type: research