IGF-I deficiency, longevity and cancer protection of patients with Laron syndrome

Publication date: Available online 5 August 2016 Source:Mutation Research/Reviews in Mutation Research Author(s): Zvi Laron, Rivka Kauli, Lena Lapkina, Haim Werner Laron syndrome (LS) is a unique model of congenital IGF-I deficiency. It is characterized by dwarfism and obesity, and is caused by deletion or mutations of the growth hormone receptor (GH-R) gene. It is hypothesized that LS is an old disease originating in Indonesia and that the mutated gene spread to South Asia, the Middle East, the Mediterranean region and South America.
Source: Mutation Research Reviews in Mutation Research - Category: Genetics & Stem Cells Source Type: research