BALF CD103+CD4+/CD4+ ratio alone is enough to support the diagnosis of sarcoidosis in an appropriate clinicopathologic setting

We read with great interest the article by Mota et al. on the diagnostic value of CD103 expression in bronchoalveolar lymphocytes in sarcoidosis.1 The authors conclude that a cutoff of 0.45 for the the bronchoalveolar lavage fluid (BALF) CD103+CD4+/CD4+ ratio was associated with a better diagnostic performance for pulmonary sarcoidosis. Combined use of the BALF CD103/CD4 ratio2.5 was reported by Kolopp-Sarda et al.2 and BALF CD103+CD4+/CD4+ ratio3 or BALF CD4+/CD8+ to peripheral blood (PB) CD4+/CD8+ ratio>2 has been reported by Heron et al.
Source: Respiratory Medicine CME - Category: Respiratory Medicine Authors: Tags: Correspondence Source Type: research