Gestational food restriction decreases placental IL10 expression and markers of autophagy and ER stress in murine intrauterine growth restriction

Intrauterine growth restriction (IUGR) affects up to 10% of pregnancies and often results in short- and long- term sequelae for offspring. The mechanisms underlying IUGR are poorly understood, but it is known that healthy placentation is essential for nutrient provision to fuel fetal growth, and is regulated by immunologic inputs. We hypothesized that in pregnancy, maternal food restriction (FR) resulting in IUGR would decrease the overall immunotolerant milieu in the placenta, leading to increased cellular stress and death.

Source: Nutrition Research - August 4, 2016 Category: Nutrition Authors: Alison Chu, Shanthie Thamotharan, Amit Ganguly, Madhuri Wadehra, Matteo Pellegrini, Sherin U. Devaskar Tags: Original Research Source Type: research