Malignant Melanoma of the Nail Apparatus: A Fluorescence In Situ Hybridization Analysis of 7 Cases

Conclusions. RREB1 and CCND1 gains are common in nail apparatus melanoma as in most melanomas, and an increased number of genetic aberrations may be associated with a poorer prognosis, though the limited number of cases precludes definitive correlation. FISH appears to be a useful adjunct in the diagnosis of nail apparatus melanomas and improves diagnostic confidence even in the setting of unambiguous histomorphology.

http://ijs.sagepub.com/cgi/content/abstract/24/6/512?rss=1

Source: International Journal of Surgical Pathology - August 4, 2016 Category: Pathology Authors: Romano, R. C., Shon, W., Sukov, W. R. Tags: Original Articles Source Type: research