Host Th1/Th2 immune response to Taenia solium cyst antigens in relation to cyst burden of neurocysticercosis
This study examined ex vivo CD4+ T cells and in vitro Th1 and Th2 cytokine responses to T solium cyst antigens of peripheral blood mononuclear cells of healthy subjects from endemic and non‐endemic regions and of single and multi‐cyst infected patients for association to cyst burden of neurocysticercosis.
T solium cyst antigens elicited a Th1 cytokine response in healthy subjects of T solium endemic and non‐endemic regions and those with single cyst infections and a Th2 cytokine response from subjects with multi‐cyst neurocysticercosis. Multi‐cyst neurocysticercosis subjects also exhibited low levels of effector memory CD4+T cells.
Th1 cytokine response of T solium exposure and low infectious loads may aid in limiting cyst number. Th2 cytokines and low effector T cells may enable multiple cysts infections to establish and persist.
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Source: Parasite Immunology - Category: Parasitology Authors: Jayaraman Tharmalingam, Prabhakar T Appaswamy, Prakash Gangadaran, Pierre Dorny, Jozef Vercruysse, Peter Geldhof, Rajshekhar Vedantam, Mathew Alexander, Anna Oommen Tags: Original Paper Source Type: research
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