The ginger component 6 ‐shogaol prevents TNF‐α‐induced barrier loss via inhibition of PI3K/Akt and NF‐κB signaling

Conclusion: 6‐SG has barrier‐protective effects by affecting TNF‐α‐induced claudin‐2 upregulation and claudin‐1 disassembly via inhibition of PI3K/Akt and NF‐κB signaling. Therefore, 6‐SG‐containing food might be beneficial for barrier preservation during intestinal inflammation.This article is protected by copyright. All rights reserved

Source: Nahrung / Food - August 3, 2016 Category: Nutrition Authors: Julia Luettig, Rita Rosenthal, In ‐Fah M. Lee, Susanne M. Krug, Jörg D. Schulzke Tags: Research Article Source Type: research