Add-on perampanel in Lance –Adams syndrome

Publication date: 2016 Source:Epilepsy & Behavior Case Reports, Volume 6 Author(s): Bernhard J. Steinhoff, Matthias Bacher, Christoph Kurth, Anke M. Staack, Reinhold Kornmeier Perampanel (PER) is the first-in-class selective, noncompetitive α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist that has been licensed and marketed as antiepileptic drug (AED) indicated for patients with partial-onset and primary generalized tonic–clonic seizures. A positive effect was reported in some patients with epileptic myoclonic jerks in idiopathic generalized epilepsy and in progressive myoclonic epilepsy. We treated a male patient with posthypoxic nonepileptic myoclonus (Lance–Adams syndrome) with add-on PER and achieved an almost complete cessation of jerks. This effect was reproducible and, therefore, we suggest that it might be worth trying PER in comparable cases.

Source: Epilepsy and Behavior Case Reports - August 3, 2016 Category: Neurology Source Type: research