Low-protein diet induces, whereas high-protein diet reduces hepatic FGF21 production in mice, but glucose and not amino acids upregulate FGF21 in cultured hepatocytes

This study aimed to investigate how dietary carbohydrates and proteins impact FGF21 production and how in turn, FGF21 is involved in the metabolic adaptation to changes in the carbohydrate and protein contents of the diet. For that purpose, we fed 25 male C57BL/6 mice diets composed of different protein and carbohydrate contents (normal-protein and carbohydrate diet (N=9, NPNC), low-protein high-carbohydrate diet (N=8, LPHC), high-protein low-carbohydrate diet (N=8, HPLC) for 3 weeks.

Source: The Journal of Nutritional Biochemistry - July 24, 2016 Category: Biochemistry Authors: Tristan Chalvon-Demersay, Patrick C. Even, Daniel Tom é, Catherine Chaumontet, Julien Piedcoq, Claire Gaudichon, Dalila Azzout-Marniche Source Type: research