Resveratrol improves TNF- α-induced endothelial dysfunction in a co-culture model of a Caco-2 with an endothelial cell line

The bioactivity of trans-Resveratrol (RSV), an important wine polyphenol, and of its metabolites was investigated in a more relevant setup comprising an in vitro co-culture cell model that combines intestinal absorption and conjugation with changes in endothelial function, which is primarily affected in cardiovascular diseases. Caco-2 and endothelial EA.hy926 cells were grown in a co-culture and Caco-2 cells were treated with RSV, in the co-culture and in two different sequential setups, for 4 h and 24 h.

Source: The Journal of Nutritional Biochemistry - August 2, 2016 Category: Biochemistry Authors: Isabela Maia Toaldo, John Van Camp, Gerard Bryan Gonzales, Senem Kamiloglu, Marilde T. Bordignon-Luiz, Guy Smagghe, Katleen Raes, Esra Capanoglu, Charlotte Grootaert Source Type: research