PD-L1 and PD-L2 Genetic Alterations Define Classical Hodgkin Lymphoma and Predict Outcome [Rapid Communication]

Conclusion
PD-L1/PD-L2 alterations are a defining feature of cHL. Amplification of 9p24.1 is more common in patients with AS disease and associated with shorter PFS in this series. Further analyses of 9p24.1 alterations in patients treated with standard cHL induction regimens or checkpoint blockade are warranted.

Source: Journal of Clinical Oncology - August 2, 2016 Category: Cancer & Oncology Authors: Roemer, Advani, Ligon, Natkunam, Redd, Homer, Connelly, Sun, Daadi, Freeman, Armand, Chapuy, de Jong, Hoppe, Neuberg, Rodig, Shipp Tags: Biology & Immunology, Rapid Communications, Rapid Communications Source Type: research