A new experimental model of acid- and endotoxin-induced acute lung injury in rats

In conclusion, intratracheal instillation of HCl followed by LPS at the dose of 30 μg/g body wt results in severe diffuse alveolar damage that continues at least 72 h. This rat model of aspiration pneumonia-induced ALI will be useful for testing long-term effects of new therapeutic strategies in ALI.

Source: AJP: Lung Cellular and Molecular Physiology - July 31, 2016 Category: Respiratory Medicine Authors: Puig, F., Herrero, R., Guillamat-Prats, R., Gomez, M. N., Tijero, J., Chimenti, L., Stelmakh, O., Blanch, L., Serrano-Mollar, A., Matthay, M. A., Artigas, A. Tags: CALL FOR PAPERS Source Type: research