Dynamics and epitope specificity of anti-human leukocyte antibodies following renal allograft nephrectomy

Conclusions Both Nx and WD-MIS contribute to alloimmunization with differing patterns concerning class I and II HLAabs. Nx preferentially increased class I HLAabs and most of the observed class I HLAabs were DESA. Considering that class I, but not class II, HLA molecules are constitutively expressed, our results support the hypothesis that the increase of HLAabs following Nx might have been caused by removal of the adsorbing donor tissue (sponge hypothesis).
Source: Nephrology Dialysis Transplantation - Category: Urology & Nephrology Authors: Tags: Renal Transplantation Source Type: research