The Effect of Cell Dose on the Early Magnetic Resonance Morphological Outcomes of Autologous Cell Implantation for Articular Cartilage Defects in the Knee: A Randomized Clinical Trial
Conclusion:
This study reveals a trend toward earlier recovery after treatment with higher spheroid doses in terms of better defect filling for full-thickness cartilage defects of the knee, while outcomes after 12 months were similar in all dose groups. However, a correlation with clinical outcomes or the failure rate at 1 year after ACI was not found. A longer follow-up will be required for more definite conclusions on the clinical relevance of ACI cell density to be drawn.
Registration:
NCT01225575 (ClinicalTrials.gov identifier); 2009-016816-20 (EudraCT number).
Source: The American Journal of Sports Medicine - Category: Sports Medicine Authors: Niemeyer, P., Laute, V., John, T., Becher, C., Diehl, P., Kolombe, T., Fay, J., Siebold, R., Niks, M., Fickert, S., Zinser, W. Tags: Knee, articular cartilage Source Type: research
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