bFGF- and CaPP-Loaded Fibrin Clots Enhance the Bioactivity of the Tendon-Bone Interface to Augment Healing

Conclusion:
bFGF- and CaPP-loaded fibrin clots enhanced cell migration and proliferation and the expression of related genes and proteins, which increased the bioactivity of the tendon-bone interface and resulted in the histological improvement of tendon-to-bone healing.

Clinical Relevance:
As fibrin clots have already been used in clinical practice, bFGF- and CaPP-loaded fibrin clots can be further used to augment healing in the early stages of tendon-to-bone healing.

Source: The American Journal of Sports Medicine - July 31, 2016 Category: Sports Medicine Authors: Zhang, C., Li, Q., Deng, S., Fu, W., Tang, X., Chen, G., Qin, T., Li, J. Tags: Growth factors/Healing enhancement, Tissue engineering, Biologic healing enhancement Biology and Translational Research Source Type: research