Platelet-Rich Plasma Activates Proinflammatory Signaling Pathways and Induces Oxidative Stress in Tendon Fibroblasts

Conclusion:
PRP induces an inflammatory response in tendon fibroblasts, which leads to the formation of ROS and the activation of oxidative stress pathways. PRP does not appear to significantly modulate macrophage polarization.

Clinical Relevance:
PRP might act by inducing a transient inflammatory event, which could then trigger a tissue regeneration response.

Source: The American Journal of Sports Medicine - July 31, 2016 Category: Sports Medicine Authors: Hudgens, J. L., Sugg, K. B., Grekin, J. A., Gumucio, J. P., Bedi, A., Mendias, C. L. Tags: Biology of tendon, Cell/Molecular biology, Growth factors/Healing enhancement Biology and Translational Research Source Type: research