Synthesis and biological activity of FGLamide allatostatin analogs with Phe3 residue modifications

This study will be useful for the design of new allatostatin analogs for insect management. Copyright © 2016 European Peptide Society and John Wiley & Sons, Ltd. A series of Phe3 residue‐modified analogs were designed and synthesized. Bioassay results indicated that analogs 4, 11 and 13 showed stronger ability than lead H17 to inhibit JH production by corpora allata of Diploptera punctata. Removing the methylene group of Phe3, or an o‐ or p‐ halogen‐substituted benzene ring could increase the activity of the analogs containing six‐membered aromatic rings.

http://onlinelibrary.wiley.com/resolve/doi?DOI=10.1002%2Fpsc.2906

Source: Journal of Peptide Science - July 31, 2016 Category: Biochemistry Authors: Yong Xie, Meizi Wang, Li Zhang, Xiaoqing Wu, Xinling Yang, Stephen S. Tobe Tags: Research Article Source Type: research