Hsp90-binding immunophilin FKBP51 forms complexes with  hTERT enhancing telomerase activity

FK506-binding proteins are members of the immunophilin family of proteins. Those immunophilins associated to the 90-kDa-heat-shock protein, Hsp90, have been proposed as potential modulators of signalling cascade factors chaperoned by Hsp90. FKBP51 and FKBP52 are the best characterized Hsp90-bound immunophilins first described associated to steroid-receptors. The reverse transcriptase subunit of telomerase, hTERT, is also an Hsp90 client-protein and is highly expressed in cancer cells, where it is required to compensate the loss of telomeric DNA after each successive cell division.

Source: Molecular Oncology - May 16, 2016 Category: Cancer & Oncology Authors: Mariana Lagadari, Nadia R. Zgajnar, Luciana I. Gallo, Mario D. Galigniana Source Type: research