Regulation of TBK1 activity by Optineurin contributes to cell cycle-dependent expression of the interferon pathway

Innate immunity is a host mechanism found in most multicellular organisms that serves as a first line of defense against microbial pathogens. The innate immune response results in the production of immune modulatory cytokines and the mobilization of cells of the immune system. Detection of pathogen associated molecular patterns (PAMPS) by the pattern-recognition receptors (PRR) activates intracellular signaling pathways that culminate in the production and secretion of pro-inflammatory cytokines, chemokines and type I IFN, i.e.
Source: Cytokine and Growth Factor Reviews - Category: Molecular Biology Authors: Tags: Mini review Source Type: research