The unique role of STAT2 in constitutive and IFN-induced transcription and antiviral responses

Interferons (IFNs) are a subset of cytokines that have profound effects on many aspects of cell physiology. IFNs regulate cell proliferation, apoptosis and inflammation but also take part in the first line of defense against viral infections. IFNs represent a family of molecules which can be divided into three main subfamilies: Type I, Type II and Type III. Type I (IFN-I) consist of IFN β, IFNκ, IFNω, IFNε and 13 subtypes of IFNα, type II (IFN-II) consists of the single IFNγ while type III (IFN-III) comprises IFNλ1, IFNλ2, IFNλ3 [1,2] and recently discovered IFNλ4 [3].
Source: Cytokine and Growth Factor Reviews - Category: Molecular Biology Authors: Tags: Mini review Source Type: research