Inflammatory microenvironment and human papillomavirus-induced carcinogenesis

The seminal observations linking inflammation and cancers dated back to mid nineteenth century when Virchow noticed that tumors tended to occur at sites of chronic inflammation. The hypothesis of a connection between inflammation and cancer was subsequently challenged by data demonstrating that acute inflammation contributed to cancer regression, even if epidemiologic studies supported that chronic inflammatory diseases are frequently associated with increased risk of cancers [1]. Nowadays, it has been realized that the development of cancers from inflammation might be a process driven by inflammatory cells as well as a variety of mediators, including cytokines, chemokines and enzymes, which altogether establish an inflammatory microenvironment [1].
Source: Cytokine and Growth Factor Reviews - Category: Molecular Biology Authors: Tags: Mini review Source Type: research