Interleukin-4 receptor signaling and its binding mechanism: A therapeutic insight from inhibitors tool box

IL-4, a cytokine discovered in the 1980 ’s, remains in the spotlight as a target for designing a potent small molecular inhibitor. This cytokine is primarily produced by basophils, mast cells, and eosinophils, beside Th2 lymphocytes [1]. Its molecular weight varies between 12 and 20KDa because of irregular pattern of post-translational modification, particularly glycosylation. This cytokine shares most of cell surface receptors, sequence homology, intracellular signaling and limited functional effects with the IL-13 cytokine [2].
Source: Cytokine and Growth Factor Reviews - Category: Molecular Biology Authors: Source Type: research