Exogenous spermine inhibits hypoxia/ischemia-induced myocardial apoptosis via regulation of mitochondrial permeability transition pore and associated pathways

In conclusion, H/I decreased endogenous spermine concentrations in cardiomyocytes, which ultimately induced apoptosis. The addition of exogenous spermine effectively prevented myocyte cell death.

Source: Experimental Biology and Medicine - July 28, 2016 Category: Research Authors: Wei, C., Li, H., Wang, Y., Peng, X., Shao, H., Li, H., Bai, S., Xu, C. Tags: Biochemistry & amp;amp; Molecular Biology Source Type: research