Blood flow and mass transfer regulation of coagulation

Blood flow regulates coagulation and fibrin formation by controlling the transport, or mass transfer, of zymogens, co-factors, enzymes, and inhibitors to, from, and within a growing thrombus. The rate of mass transfer of these solutes relative to their consumption or production by coagulation reactions determines, in part, the rate of thrombin generation, fibrin deposition, and thrombi growth. Experimental studies on the influence of blood flow on specific coagulation reactions are reviewed here, along with a theoretical framework that predicts how flow influences surface-bound coagulation binding and enzymatic reactions.

Source: Blood Reviews - April 14, 2016 Category: Hematology Authors: Kuldeepsinh Rana, Keith B. Neeves Tags: REVIEW Source Type: research