Diagnosis and endoscopic management of primary sclerosing cholangitis

Primary sclerosing cholangitis (PSC) is a complex, chronic, and progressive fibroinflammatory destructive cholestatic biliary disease. The exact etiology and pathogenesis are unknown and possibly related to an enhanced immune-mediated response and reaction in the biliary system. PSC is closely associated with inflammatory bowel disease and specifically, ulcerative colitis. It can be characterized by both intrahepatic and extrahepatic bile duct stricturing and dilation. Clinical manifestations include abnormal liver tests, jaundice, pruritus, and fatigue.
Source: Techniques in Gastrointestinal Endoscopy - Category: Gastroenterology Authors: Tags: SI: Imaging in IBD Source Type: research