Prolactin role in the bovine uterus during adenomyosis

Adenomyosis is uterine dysfunction defined as the presence of endometrial glands within the myometrium. It is suggested that adenomyosis is oestrogen-dependent pathology, and prolactin (PRL) also affects its development. In the uterus of ruminants, PRL stimulates gland proliferation and function. We hypothesised that in the bovine uterus, expression of PRL and its receptors (PRLRs) during adenomyosis is disturbed and modulated by oestradiol (E2). Uterine tissues were collected post mortem from cows; epithelial, stromal and myometrial cells were isolated; and cultured and treated with E2.

Source: Domestic Animal Endocrinology - July 21, 2016 Category: Endocrinology Authors: M. Łupicka, B.M. Socha, A.A. Szczepańska, A.J. Korzekwa Source Type: research