Abstract < /h3 > < p class= " a-plus-plus " > Mycosis fungoides is the most common type of primary cutaneous T cell lymphoma. We have evaluated < em class= " a-plus-plus " > CDKN2A < /em > losses and < em class= " a-plus-plus " > MYC < /em > gains/amplifications by FISH analysis, as well as expression of < em class= " a-plus-plus " > miR-155 < /em > and members of ..."> Abstract < /h3 > < p class= " a-plus-plus " > Mycosis fungoides is the most common type of primary cutaneous T cell lymphoma. We have evaluated < em class= " a-plus-plus " > CDKN2A < /em > losses and < em class= " a-plus-plus " > MYC < /em > gains/amplifications by FISH analysis, as well as expression of < em class= " a-plus-plus " > miR-155 < /em > and members of ..." /> Abstract < /h3 > < p class= " a-plus-plus " > Mycosis fungoides is the most common type of primary cutaneous T cell lymphoma. We have evaluated < em class= " a-plus-plus " > CDKN2A < /em > losses and < em class= " a-plus-plus " > MYC < /em > gains/amplifications by FISH analysis, as well as expression of < em class= " a-plus-plus " > miR-155 < /em > and members of ..." />

Genomic imbalances and microRNA transcriptional profiles in patients with mycosis fungoides

< h3 class= " a-plus-plus " > Abstract < /h3 > < p class= " a-plus-plus " > Mycosis fungoides is the most common type of primary cutaneous T cell lymphoma. We have evaluated < em class= " a-plus-plus " > CDKN2A < /em > losses and < em class= " a-plus-plus " > MYC < /em > gains/amplifications by FISH analysis, as well as expression of < em class= " a-plus-plus " > miR-155 < /em > and members of the oncogenic cluster < em class= " a-plus-plus " > miR-17-92 < /em > ( < em class= " a-plus-plus " > miR17 < /em > , < em class= " a-plus-plus " > miR18a < /em > , < em class= " a-plus-plus " > miR19b < /em > , and < em class= " a-plus-plus " > miR92a < /em > ) in MF patients with advanced disease. Formalin-fixed paraffin-embedded skin biopsies from 36 patients at diagnosis, 16 with tumoral MF (T-MF), 13 in histological transformation to a large T cell lymphoma (TR-MF), and 7 cases with folliculotropic variant (F-MF), were studied. Twenty cases showed genomic alterations (GAs): 8 (40  %) had < em class= " a-plus-plus " > CDKN2A < /em > deletion, 7 (35  %) showed < em class= " a-plus-plus " > MYC < /em > gain, and 5 (25  %) exhibited both alterations. GAs were more frequently observed in F-MF ( < em class= " a-plus-plus " > p < /em >  = 0.004) and TR-MF ( < em class= " a-plus-plus " > p < /em >  = 0.0001) than T-MF. GAs were significantly higher in cases presenting lesions in head, neck, and lower extremities compared to those observed in trunk and upper extremities ( < em ...
Source: Tumor Biology - Category: Cancer & Oncology Source Type: research